To be completely honest, I have always been feeling quite uncomfortable wearing leopard prints. Nevertheless, that changed 1 year ago, when I started to appreciate it. I think It will be always trendy, as long as you know how to wear it.
One leopard piece, for example, jacket, shoes or a bag will be perfect. On the other hand, if you mix all of them at a time, that could be a real fashion stumble-upon.
In the summer I prefer leopard prints in gray. It is easy to wear with boots, just like I did that day in Canario Garden, Gran Canaria. For the winter season, I prefer wearing the real leopard prints, of brown and black colors.
In any case, a leopard print piece is nice idea to have a nice touch on your outfit. But pay attention, not to do too much.
Boots: Zara (old collection), I like these ones
Bag: like this one from MyTheressa